3-(4-甲氧基苯基)丙酸合成路线 （共 94 条）
反应条件
Novozym 435; acylase I from Aspergillus melleus; amano lipase AK from pseudomonas fluorescens; lipase from wheat germ; papaine in toluene
T=40°C; 48 h; Enzymatic reaction; Mechanism;
参考文献
Zysk, Malgorzata; Zadlo, Anna; Brodzka, Anna; Wisniewska, Catalina; Ostaszewski, Ryszard
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 102, p. 225 - 229
反应条件
1: 3-(4-methoxyphenyl)-propionic acid With 1H-imidazole; iodine; tris-(o-tolyl)phosphine in dichloromethane
T=20°C; Garegg-Samuelsson type reaction; 0.0833333 h;
2: ethanol With isopropyl alcohol in dichloromethane
T=20°C; Garegg-Samuelsson type reaction; chemoselective reaction;
参考文献
Morcillo, Sara P.; Alvarez De Cienfuegos, Luis; Mota, Antonio J.; Justicia, Jose; Robles, Rafael
Journal of Organic Chemistry, 2011 , vol. 76, # 7 p. 2277 - 2281
参考文献
Molina; Fresneda; Sanz
Journal of Organic Chemistry, 1999 , vol. 64, # 7 p. 2540 - 2544
反应条件
H4SiW12O40; bis-[(trifluoroacetoxy)iodo]benzene in acetonitrile
T=0 - 20°C;
参考文献
Hata, Kayoko; Hamamoto, Hiromi; Shiozaki, Yukiko; Kita, Yasuyuki
Chemical Communications, 2005 , # 19 p. 2465 - 2467
反应条件
1.1: sulfuric acid / 3.5 h / |Reflux; |Inert atmosphere
2.1: diisobutylaluminium hydride / tetrahydrofuran / 2.5 h / -78 °C / |Inert atmosphere
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / |Inert atmosphere
3.2: 0.33 h / 20 °C / |Inert atmosphere
4.1: toluene / 0.33 h / |Inert atmosphere; |Reflux
5.1: hydrogen; palladium on activated charcoal / ethanol / 10 h / 20 °C / |Inert atmosphere
6.1: hydrogen bromide / acetic acid / 3 h / |Inert atmosphere; |Reflux
View Scheme
参考文献
Thuaud, Frederic; Kojima, Shuntaro; Hirai, Go; Oonuma, Kana; Tsuchiya, Ayako; Uchida, Takako; Tsuchimoto, Teruhisa; Sodeoka, Mikiko
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 9 p. 2771 - 2782
反应条件
1: 97.5 percent / lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 0.5 h, 2.) 25 deg C, 5 h
2: 83 percent / chromium trioxide, pyridine / CH2Cl2 / 0.17 h / 25 °C
3: 86 percent / 1.) sodium hydride, Me2SO / 1.) 65 deg C, 1.5 h, 2.) THF, 0 deg C, 0.5 h; 25 deg C, 2 h
View Scheme
参考文献
Semmelhack, M.F.; Helquist, Paul; Jones, L.D.; Keller, Leonard; Mendelson L.; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 21 p. 6460 - 6471
反应条件
1: 97.5 percent / lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 0.5 h, 2.) 25 deg C, 5 h
2: 83 percent / chromium trioxide, pyridine / CH2Cl2 / 0.17 h / 25 °C
3: 94 percent / 1.) boron trifluoride etherate / CH2Cl2 / 1.) 0 deg C, 0.5 h, 2.) 25 deg C, 1.5 h
View Scheme
参考文献
Semmelhack, M.F.; Helquist, Paul; Jones, L.D.; Keller, Leonard; Mendelson L.; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 21 p. 6460 - 6471
反应条件
1: LiAlH4 / tetrahydrofuran
2: PBr3
View Scheme
参考文献
Steller,K.E.; Letsinger,R.L.
Journal of Organic Chemistry, 1970 , vol. 35, p. 308 - 313
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Hashimoto, Kimiko; Sakai, Mitsuru; Okuno, Toshikatsu; Shirahama, Haruhisa
Chemical Communications, 1996 , # 10 p. 1139 - 1140
反应条件
1: polyphosphoric acid
2: (i), (ii) Al2O3, benzene
View Scheme
参考文献
Hofer,O.
Monatshefte fuer Chemie, 1978 , vol. 109, p. 405 - 419
反应条件
1: LiAlH4
2: PBr3
3: NaOEt / ethanol
4: aq. NaOH
View Scheme
参考文献
Hashimoto, Kimiko; Sakai, Mitsuru; Okuno, Toshikatsu; Shirahama, Haruhisa
Chemical Communications, 1996 , # 10 p. 1139 - 1140
