4,4'-二甲氧基二苯甲胺合成路线 （共 11 条）
参考文献
Nature (London, United Kingdom), , vol. 165, p. 400
反应条件
1: in tetrahydrofuran T=0 - 60°C; 7.17 h; 2: With sodium tetrahydroborate in tetrahydrofuran; methanol T=0 - 20°C;
参考文献
GLAXO GROUP LIMITED; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby; WANG, Yonghui
Patent: WO2013/85890 A1, 2013 ;
Location in patent: Page/Page column 33 ;
反应条件
ammonia in chloroform 2 h;
参考文献
Acheson; Bite; Kemp
Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1300 - 1304
反应条件
1: Et3N / tetrahydrofuran / -78 - -20 °C 2: 15.59 g / liq. ammonia / tetrahydrofuran / -78 - 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 22 p. 7185 - 7194
反应条件
sodium tetrahydroborate in methanol 2 h;
参考文献
Dejaegher; Mangelinckx; De Kimpe
Synlett, 2002 , # 1 p. 113 - 115
反应条件
1: 2.) formamide, MgCl2 / 1.) 180-190 deg C, 4 h; 2.) 180-190 deg C, 2 h 2: 8.48 g / 1M HCl / methanol / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 45, # 18 p. 5767 - 5790
反应条件
1.1: I2; Mg / tetrahydrofuran / 0.75 h / Heating 1.2: tetrahydrofuran / 5 h / Heating 2.1: 94 percent / NaBH4 / methanol / 2 h View Scheme
参考文献
Synlett, , # 1 p. 113 - 115
反应条件
hydrogenchloride in methanol 2 h; Heating;
参考文献
Ito; Kobayashi; Kawabata; Takase; Terashima
Tetrahedron, 1989 , vol. 45, # 18 p. 5767 - 5790
反应条件
1.1: I2; Mg / tetrahydrofuran / 0.75 h / Heating 1.2: tetrahydrofuran / 5 h / Heating 2.1: 94 percent / NaBH4 / methanol / 2 h View Scheme
参考文献
Synlett, , # 1 p. 113 - 115
反应条件
aluminium trichloride T=90°C; Verseifen des Reaktionsprodukts;
参考文献
DE103858 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 5, p. 72
