乙基1-乙酰基-1H-吲唑-5-羧酸酯合成路线 （共 7 条）
反应条件
1.1: hydrogenchloride; water / ethanol / 15 h / 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h 2.2: 20 °C View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1.1: hydrogenchloride; water / ethanol / 15 h / 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h 2.2: 20 °C View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
hydrogenchloride Hydrolysis;
参考文献
Batt, Douglas G.; Harlow, Patricia P.; Barbera, Frank A.; Spitz, Susan M.; Wexler, Ruth R.; Jadhav, Prabhakar K.; Petraitis, Joseph J.; Houghton, Gregory C.; Modi, Dilip P.; Cain, Gary A.; Corjay, Martha H.; Mousa, Shaker A.; Bouchard, Peter J.; Forsythe, Mark S.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 1 p. 41 - 58
反应条件
1: With potassium acetate in chloroform
1 h;
2: With 18-crown-6 ether; isopentyl nitrite in chloroform
21 h; Reflux;
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
Location in patent: Paragraph 0284; 0285;0286;0287; 0288 ;
反应条件
18-crown-6 ether; n-Pentyl nitrite in chloroform
diazotization; cyclization; Heating;
参考文献
Batt, Douglas G.; Harlow, Patricia P.; Barbera, Frank A.; Spitz, Susan M.; Wexler, Ruth R.; Jadhav, Prabhakar K.; Petraitis, Joseph J.; Houghton, Gregory C.; Modi, Dilip P.; Cain, Gary A.; Corjay, Martha H.; Mousa, Shaker A.; Bouchard, Peter J.; Forsythe, Mark S.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 1 p. 41 - 58
反应条件
1: KOAc / CHCl3
2: 18-crown-6; n-amyl nitrite / CHCl3 / Heating
View Scheme
参考文献
Batt, Douglas G.; Harlow, Patricia P.; Barbera, Frank A.; Spitz, Susan M.; Wexler, Ruth R.; Jadhav, Prabhakar K.; Petraitis, Joseph J.; Houghton, Gregory C.; Modi, Dilip P.; Cain, Gary A.; Corjay, Martha H.; Mousa, Shaker A.; Bouchard, Peter J.; Forsythe, Mark S.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 1 p. 41 - 58
反应条件
1.1: sulfuric acid / 3 h / |Reflux
2.1: potassium acetate / chloroform / 1 h
2.2: 21 h / |Reflux
View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
