N-[3-(甲氧羰基)苯基]硫代氨基亚胺酸合成路线 （共 4 条）
反应条件
1: methyl 3-amino-benzoate With sulfuric acid in chlorobenzene T=-10°C; 0.25 h; 2: sodium isothiocyanate in chlorobenzene 0.5 h; 3: With 18-crown-6 ether in chlorobenzene T=100°C; 16 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/81399 A2, 2008 ;
Location in patent: Page/Page column 78 ;
WO 2008/081399 A2
反应条件
1: methyl 3-amino-benzoate With sulfuric acid in chlorobenzene T=-10°C; 0.25 h; 2: potassium thioacyanate With 18-crown-6 ether in chlorobenzene T=100°C; 20.5 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/104155 A1, 2009 ;
Location in patent: Page/Page column 58 ;
WO 2009/104155 A1
反应条件
sulfuric acid in chlorobenzene
参考文献
Novartis Corporation
Patent: US5770758 A1, 1998 ;
反应条件
1: With bromine; acetic acid T=0 - 70°C; 4 h; 2: With sodium hydrogencarbonate in water
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/104155 A1, 2009 ;
Location in patent: Page/Page column 58 ;
WO 2009/104155 A1
