3-羟基-2,2-二甲基丙腈合成路线 （共 16 条）
反应条件
2: Et3N / dimethylsulfoxide View Scheme
参考文献
Kern,J.M.; Federli,P.
Bulletin de la Societe Chimique de France, 1972 , p. 4379 - 4383
反应条件
tetrafluoroboric acid in n-heptane; dichloromethane T=0°C; 1.66667 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2007/28051 A2, 2007 ;
Location in patent: Page/Page column 49-50 ;
WO 2007/028051 A2
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Edmundson, R. S.
Organic Mass Spectrometry, 1982 , vol. 17, # 11 p. 558 - 564
参考文献
Boehm
Monatshefte fuer Chemie, 1906 , vol. 27, p. 955
反应条件
potassium permanganate; water
参考文献
Boehm
Monatshefte fuer Chemie, 1906 , vol. 27, p. 955
反应条件
1.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.42 h / -78 °C
1.2: -78 - 25 °C
2.1: methanol; water; hydrogenchloride / 1 h / 55 °C
3.1: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 0.25 h / 25 °C
View Scheme
参考文献
Cieslak, Jacek; Ausin, Cristina; Grajkowski, Andrzej; Beaucage, Serge L.
Chemistry - A European Journal, 2013 , vol. 19, # 14 p. 4623 - 4632
