1-溴-3-(2,2-二甲氧基-乙基磺酰基)-苯合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=30°C;
参考文献
TARGEGEN INC.
Patent: WO2009/49028 A1, 2009 ;
Location in patent: Page/Page column 87 ;
WO 2009/049028 A1
反应条件
1: 3-bromobenzenethiol With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h; 2: bromoacetaldehyde dimethylacetal in N,N-dimethyl-formamide T=20°C; 2 h; Product distribution / selectivity;
参考文献
Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P.
Patent: US2006/52378 A1, 2006 ;
Location in patent: Page/Page column 128-130 ;
US 20060052378 A1
反应条件
poliphosphoric acid in chlorobenzene 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
TARGEGEN INC.
Patent: WO2009/49028 A1, 2009 ;
Location in patent: Page/Page column 88 ;
WO 2009/049028 A1
反应条件
poliphosphoric acid in chlorobenzene 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
TARGEGEN INC.
Patent: WO2009/49028 A1, 2009 ;
Location in patent: Page/Page column 88 ;
WO 2009/049028 A1
反应条件
PPA in chlorobenzene Heating;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
1: PPA / chlorobenzene / Heating
2: SnCl4 / 1,2-dichloro-ethane / 0 - 20 °C
3: aq. NaOH; Br2 / dioxane / 0 - 20 °C
4: CuBr; Cu / methanol / Heating
View Scheme
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
