4-(4-氯-2-氟苯基氨基)-7-羟基-6-甲氧基喹唑啉合成路线 （共 4 条）
反应条件
1: 71 percent / propan-2-ol / 1.5 h / Heating 2: 72 percent / TFA / 0.83 h / Heating View Scheme
参考文献
Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226
反应条件
1.1: dioxane / 24 h / Heating 1.2: 84 percent / NaOAc; AcOH / 3 h / Heating 2.1: SOCl2; DMF / Heating 3.1: 71 percent / propan-2-ol / 1.5 h / Heating 4.1: 72 percent / TFA / 0.83 h / Heating View Scheme
参考文献
Hennequin, Laurent F.; Thomas, Andrew P.; Johnstone, Craig; Stokes, Elaine S. E.; Ple, Patrick A.; Lohmann, Jean-Jacques M.; Ogilvie, Donald J.; Dukes, Mike; Wedge, Steve R.; Curwen, Jon O.; Kendrew, Jane; Lambert-Van Der Brempt, Christine
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5369 - 5389
反应条件
1: SOCl2; DMF / Heating 2: 71 percent / propan-2-ol / 1.5 h / Heating 3: 72 percent / TFA / 0.83 h / Heating View Scheme
参考文献
Hennequin, Laurent F.; Thomas, Andrew P.; Johnstone, Craig; Stokes, Elaine S. E.; Ple, Patrick A.; Lohmann, Jean-Jacques M.; Ogilvie, Donald J.; Dukes, Mike; Wedge, Steve R.; Curwen, Jon O.; Kendrew, Jane; Lambert-Van Der Brempt, Christine
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5369 - 5389
反应条件
1: hydrogenchloride / isopropyl alcohol / 2 h / Reflux 2: trifluoroacetic acid / 1 h / Reflux View Scheme
参考文献
Gao, Mingzhang; Lola, Christian M.; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3222 - 3226
