(2-氯-6-甲氧基-4-吡啶)-甲醇合成路线 （共 9 条）
反应条件
lithium borohydride; ethanol in tetrahydrofuran
T=20°C; 15 h;
参考文献
MERCK SHARP and DOHME CORP.; STAMFORD, Andrew, W.; GILBERT, Eric, J.; CUMMING, Jared, N.
Patent: WO2012/138590 A1, 2012 ;
Location in patent: Page/Page column 72 ;
WO 2012/138590 A1
反应条件
boric acid trimethyl ester; dimethylsulfide borane complex in tetrahydrofuran
T=20°C; 16 h;
参考文献
Wild, Nicole; Groth, Ulrich
European Journal of Organic Chemistry, 2003 , # 22 p. 4445 - 4449
反应条件
sodium hydroxide in methanol
参考文献
Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 61 ;
US 6362336 B1
反应条件
1: 71 percent / Me4N(1+)*Cl(1-); POCl3 / 29 h / 140 - 150 °C
2: 96 percent / NaOMe / 48 h / Heating
3: BH3*THF / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E
Tetrahedron, 2002 , vol. 58, # 34 p. 6951 - 6963
反应条件
1: 96 percent / NaOMe / 48 h / Heating
2: BH3*THF / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E
Tetrahedron, 2002 , vol. 58, # 34 p. 6951 - 6963
反应条件
1: methanol / 5 h / 20 °C
2: lithium borohydride; ethanol / tetrahydrofuran / 15 h / 20 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; STAMFORD, Andrew, W.; GILBERT, Eric, J.; CUMMING, Jared, N.
Patent: WO2012/138590 A1, 2012 ;
WO 2012/138590 A1
反应条件
1: 45 percent / Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; K2CO3 / dimethylformamide / 90 °C / 775.72 Torr
2: 74 percent / Ph3P; imidazole; CBr4 / tetrahydrofuran / 3.5 h / 20 °C
View Scheme
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E
Tetrahedron, 2002 , vol. 58, # 34 p. 6951 - 6963
反应条件
1: triphenylphosphine With bromine in dichloromethane
T=0°C; 0.5 h;
2: 2-chloro-4-hydroxymethyl-6-methoxypyridine in dichloromethane
2 h;
参考文献
BIOVITRUM AB
Patent: WO2004/63156 A1, 2004 ;
Location in patent: Page 36 ;
WO 2004/063156 A1
反应条件
carbon tetrabromide; triphenylphosphine in benzene
T=20°C; 16 h;
参考文献
Wild, Nicole; Groth, Ulrich
European Journal of Organic Chemistry, 2003 , # 22 p. 4445 - 4449
