1-叔丁氧羰基哌啶-4-亚基乙酸合成路线 （共 6 条）
反应条件
sodium hydroxide in methanol T=25°C; 0.5 h;
参考文献
Wang, Xiao Jian; Xi, Mei Yang; Fu, Ji Hua; Zhang, Fu Rong; Cheng, Gui Fang; Yin, Da Li; You, Qi Dong
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 707 - 710
反应条件
sodium hydroxide in tetrahydrofuran; water 20 h;
参考文献
EP1431285 A1, ;
Page 116-117 ;
反应条件
1: With ammonium chloride; sodium t-butanolate in tert-butyl alcohol T=20 - 100°C; 0.5 h; 2: With hydrogenchloride in trans-1,3-dioxane; dichloromethane T=0 - 20°C; 1 h; 3: With sodium hydroxide; malonic acid di(tert-butyl)-ester; citric acid more than 3 stages;
参考文献
US2004/266810 A1, ;
Page/Page column 6-7 ;
反应条件
1: 10.9 g / aq. NaOH / tetrahydrofuran / 12 h / 20 °C 2: 9.5 g / toluene / 12 h / Heating 3: 5.49 g / aq. LiOH / dioxane / 12 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380
反应条件
1: 10.9 g / aq. NaOH / tetrahydrofuran / 12 h / 20 °C 2: 9.5 g / toluene / 12 h / Heating 3: 5.49 g / aq. LiOH / dioxane / 12 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380
反应条件
1: 9.5 g / toluene / 12 h / Heating 2: 5.49 g / aq. LiOH / dioxane / 12 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380
