1-甲基-3,5-二苯基-吡唑合成路线 （共 73 条）
反应条件
1: 5 wt Cu/Fe / N,N-dimethyl-formamide / 3 h / 100 °C
2: N,N-dimethyl-formamide / 5 h / 100 °C
View Scheme
参考文献
Kovacs, Szabolcs; Novak, Zoltan
Tetrahedron, 2013 , vol. 69, # 43 p. 8987 - 8993
反应条件
in ethanol
4 h; Ambient temperature;
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
反应条件
1: 70 percent / (+)-cinchonine
2: 40 percent / KHSO4 / methanol / 4 h / 50 °C
View Scheme
参考文献
Zielinska-Blajet, Mariola; Kowalczyk, Rafal; Skarzewski, Jacek
Tetrahedron, 2005 , vol. 61, # 22 p. 5235 - 5240
反应条件
1: 89 percent / BF3*Et2O / 8 h / 20 °C
2: 84 percent / acetonitrile / 0.5 h / 20 °C
View Scheme
参考文献
Stefane, Bogdan; Polanc, Slovenko
New Journal of Chemistry, 2002 , vol. 26, # 1 p. 28 - 32
反应条件
1: 3.12 g / diethyl ether; tetrahydrofuran
2: 16 percent / TiCl4 / 1,2-dichloro-benzene / 0.5 h / 115 - 125 °C
View Scheme
参考文献
Ito, Suketaka; Tanaka, Yumo; Kakehi, Akikazu; Fukuyama, Toshihiko; Osawa, Nobuo; Sayo, Noboru
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 2 p. 545 - 548
反应条件
1: 1.) sodium hydride / 1.) DMF, 2.) DMF, RT, 1 h
2: 4.40 g / thionyl chloride / 3 h / Heating
3: 16 percent / TiCl4 / 1,2-dichloro-benzene / 0.5 h / 115 - 125 °C
View Scheme
参考文献
Ito, Suketaka; Tanaka, Yumo; Kakehi, Akikazu; Fukuyama, Toshihiko; Osawa, Nobuo; Sayo, Noboru
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 2 p. 545 - 548
反应条件
1: 4.40 g / thionyl chloride / 3 h / Heating
2: 16 percent / TiCl4 / 1,2-dichloro-benzene / 0.5 h / 115 - 125 °C
View Scheme
参考文献
Ito, Suketaka; Tanaka, Yumo; Kakehi, Akikazu; Fukuyama, Toshihiko; Osawa, Nobuo; Sayo, Noboru
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 2 p. 545 - 548
反应条件
1: 63 percent / Br2 / acetic acid / 2 h / Ambient temperature
2: 72 percent / Et3N / benzene / 4 h / Heating
3: 54 percent / chloranil / xylene / 6 h / Heating
View Scheme
参考文献
Fliege, Werner; Grashey, Rudolf; Huisgen, Rolf
Chemische Berichte, 1984 , vol. 117, # 3 p. 1194 - 1214
反应条件
1: 33 percent / benzene / 2 h / Ambient temperature
2: 1 h / 135 °C
View Scheme
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
反应条件
in ethanol
T=80°C; 0.5 h;
参考文献
Baxendale, Ian R.; Schou, Seren C.; Sedelmeier, Joerg; Ley, Steven V.
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 89 - 94
