4,4-二甲基-2-苯基-2-噁唑啉合成路线 （共 73 条）
反应条件
1: 1.) BuLi / 1.) THF, -45 deg C, 2.) -100 deg C 2: 5percent aq. HCl / Heating; overnight View Scheme
参考文献
Edgar; Bradsher
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1585 - 1587
反应条件
hydroxycarbonylphosphonic acid 1.) ether, hexane, a) -78 deg C, 15 min., b) 0 deg C, 30 min., 2.) ether, hexane, a) 0 deg C, 1 h, b) RT, 5 h; Multistep reaction. Yields of byproduct given;
参考文献
Acta Chemica Scandinavica, , vol. 47, # 3 p. 318 - 322
反应条件
hydrogenchloride; n-butyllithium Multistep reaction;
参考文献
Acta Chemica Scandinavica, , vol. 47, # 3 p. 318 - 322
反应条件
n-butyllithium 1.) ether, hexane, a) -78 deg C, 15 min., b) 0 deg C, 30 min., 2.) ether, hexane, a) 0 deg C, 1 h, b) RT, 5 h; Multistep reaction. Yields of byproduct given;
参考文献
Acta Chemica Scandinavica, , vol. 47, # 3 p. 318 - 322
反应条件
1: HCl gas / diethyl ether / 0.17 h 2: 50 percent / acetonitrile / RT, 2 h, then reflux, 6 h View Scheme
参考文献
Singh, Harjit; Sarin, Rakesh
Tetrahedron, 1986 , vol. 42, # 5 p. 1449 - 1460
反应条件
1: 1.) BuLi / 1.) THF, -45 deg C, 2.) -100 deg C 2: 5percent aq. HCl / Heating; overnight View Scheme
参考文献
Edgar; Bradsher
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1585 - 1587
反应条件
1: 1.) n-butyllithium, 2.) ZnCl2, 3.) Ni(acac)2, PPh3, diisobutylaluminum hydride 2: 6 N aq. HCl / 3 h / Heating View Scheme
参考文献
Eaddy, John F.
Organic Preparations and Procedures International, 1995 , vol. 27, # 3 p. 367 - 372
反应条件
1: 1.) BuLi / 1.) THF, -45 deg C, 2.) -100 deg C 2: 5percent aq. HCl / Heating; overnight View Scheme
参考文献
Edgar; Bradsher
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1585 - 1587
反应条件
1: n-BuLi, I2 / 0 °C 2: 6 N HCl / Heating View Scheme
参考文献
Berman, Ellen M.; Showalter, H. D. Hollis
Journal of Organic Chemistry, 1989 , vol. 54, # 23 p. 5642 - 5644
反应条件
1: 1.) n-BuLi / 1.) THF, -40 deg C, 15 min, 2.) THF, RT, 1 h 2: 66 percent / conc. aq. HCl / 24 h / Heating View Scheme
参考文献
Griffiths, D. Vaughan; Griffiths, Penelope A.; Karim, Khalku; Whitehead, Belinda J.
Journal of Chemical Research, Miniprint, 1996 , # 4 p. 901 - 925
