5-叠氮基-5-脱氧胸腺嘧啶脱氧核苷合成路线 （共 15 条）
反应条件
1: 84 percent / pyridine / 26 h / 0 - 20 °C 2: trimethylsilyl triflate / acetonitrile / 24.5 h / -40 - 20 °C 3: ammonia / methanol / 16 h / Ambient temperature View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 48, # 3 p. 215 - 221
反应条件
1: trimethylsilyl triflate / acetonitrile / 24.5 h / -40 - 20 °C 2: ammonia / methanol / 16 h / Ambient temperature View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 48, # 3 p. 215 - 221
反应条件
recombinant Escherichia coli thymidine phosphorylase T=37°C; pH=6.5; aq. buffer; Kinetics;
参考文献
Panova, Natalya G.; Alexeev, Cyril S.; Polyakov, Konstantin M.; Gavryushov, Sergei A.; Kritzyn, Anatoliy M.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 12 p. 1211 - 1214
反应条件
1: H2 / 10 percent Pd/C / ethanol / 4 h 2: pyridine 3: DMAP; pyridine / 12 h 4: DCC; pyridine / dioxane View Scheme
参考文献
Reddy, Putta Mallikarjuna; Bruice, Thomas C.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1281 - 1285
反应条件
hydrogen; palladium on activated charcoal in methanol
13 h;
参考文献
Wako Pure Chemical Industries, Ltd.
Patent: US2008/64868 A1, 2008 ;
Location in patent: Page/Page column 10; 11 ;
