4-亚苄基-哌啶-1-羧酸叔丁酯合成路线 （共 13 条）
反应条件
potassium hydrogencarbonate in tetrahydrofuran; water Condensation; 1 h; Heating;
参考文献
Astra Pharma Inc.
Patent: US6130222 A1, 2000 ;
反应条件
1: phenyl (4-piperidinyl)methanone With sodium hydrogencarbonate in water T=20°C; 0.25 h; 2: di-tert-butyl dicarbonate in water T=20°C; 15 h;
参考文献
FAES FARMA, S.A.; LEDO GOMEZ, Francisco; MUNOZ MUNOZ, Ana; PUMAR DURAN, Carmen
Patent: WO2011/147780 A1, 2011 ;
Location in patent: Page/Page column 30 ;
反应条件
in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
AMGEN INC.
Patent: WO2009/75857 A2, 2009 ;
Location in patent: Page/Page column 75-76 ;
WO 2009/075857 A2
反应条件
in tetrahydrofuran T=-40 - 25°C;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/11130 A2, 2008 ;
Location in patent: Page/Page column 146-147 ;
WO 2008/011130 A2
反应条件
bis(acetylacetonate)nickel(II); bathophenanthroline; magnesium chloride; zinc in acetonitrile T=25°C; 12 h; Inert atmosphere;
参考文献
Wu, Fan; Lu, Wenbin; Qian, Qun; Ren, Qinghua; Gong, Hegui
Organic Letters, 2012 , vol. 14, # 12 p. 3044 - 3047
反应条件
1: AlCl3 / 1,2-dichloro-ethane / 2 h / Heating 2: aq. HCl / Heating 3: aq. NaHCO3 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 25 p. 5512 - 5532
反应条件
1: SOCl2 / 1 h / 20 °C 2: AlCl3 / 1,2-dichloro-ethane / 2 h / Heating 3: aq. HCl / Heating 4: aq. NaHCO3 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 25 p. 5512 - 5532
反应条件
phenylmagnesium halide in tetrahydrofuran T=-78°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 4 p. 1062 - 1066
反应条件
1: aq. HCl / Heating 2: aq. NaHCO3 / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 25 p. 5512 - 5532
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C 2: phenylmagnesium halide / tetrahydrofuran / -78 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 4 p. 1062 - 1066
