1.1: water; acetonitrile / 0.08 h 1.2: Reflux 2.1: sodium hydroxide / 2 h / 0 - 10 °C 3.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-[1,3,5]triazine / N,N-dimethyl-formamide / 4 h / Reflux 4.1: sodium hydroxide / ethanol / 1 h / Cooling View Scheme

1: sodium hydroxide / 2 h / 0 - 10 °C 2: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-[1,3,5]triazine / N,N-dimethyl-formamide / 4 h / Reflux 3: sodium hydroxide / ethanol / 1 h / Cooling View Scheme

1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-[1,3,5]triazine / N,N-dimethyl-formamide / 4 h / Reflux 2: sodium hydroxide / ethanol / 1 h / Cooling View Scheme

1.1: copper(l) iodide; diethylamine; triphenylphosphine; palladium dichloride / 4 h / 50 °C 1.2: 3.5 h / 2585.81 Torr 1.3: 1 h / -10 - 0 °C 2.1: hydrogen bromide; bromine; acetic acid / dichloromethane / Reflux 3.1: water; acetonitrile / 0.08 h 3.2: Reflux 4.1: sodium hydroxide / 2 h / 0 - 10 °C 5.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-[1,3,5]triazine / N,N-dimethyl-formamide / 4 h / Reflux 6.1: sodium hydroxide / ethanol / 1 h / Cooling View Scheme

1.1: hydrogen bromide; bromine; acetic acid / dichloromethane / Reflux 2.1: water; acetonitrile / 0.08 h 2.2: Reflux 3.1: sodium hydroxide / 2 h / 0 - 10 °C 4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-[1,3,5]triazine / N,N-dimethyl-formamide / 4 h / Reflux 5.1: sodium hydroxide / ethanol / 1 h / Cooling View Scheme