(4-溴-2-氟苯基)乙酸甲酯合成路线 （共 8 条）
反应条件
in methanol; toluene T=20°C; Inert atmosphere;
参考文献
Hadida Ruah, Sara Sabina; Kallel, Edward Adam; Miller, Mark Thomas; Arumugam, Vijayalaksmi; McCartney, Jason; Anderson, Corey; Grootenhuis, Peter Diederik Jan; Jiang, Licong
Patent: US2012/196869 A1, 2012 ;
Location in patent: Paragraph 0449; 0450; 0451 ;
US 20120196869 A1
反应条件
1: T=20 - 50°C; 4 h; 2: With water; sodium carbonate in dichloromethane
参考文献
PFIZER INC.
Patent: WO2004/74270 A2, 2004 ;
Location in patent: Page 147 ;
反应条件
potassium carbonate in acetonitrile T=0 - 60°C;
参考文献
ASTRAZENECA AB
Patent: WO2007/69986 A1, 2007 ;
Location in patent: Page/Page column 95-96 ;
WO 2007/069986 A1
参考文献
Daiichi Sankyo Company, Limited
Patent: EP1806332 A1, 2007 ;
反应条件
sulfuric acid Heating / reflux;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00604; 00651 ;
WO 2013/043232 A2
反应条件
sulfuric acid T=80°C; 72 h;
参考文献
GLAXOSMITHKLINE LLC; GHERGUROVICH, Jonathan, Michael; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; RIDGERS, Lance, Howard; YU, Hongyi
Patent: WO2013/28447 A1, 2013 ;
Location in patent: Page/Page column 93-94 ;
反应条件
1: (4-Bromo-2-fluoro-phenyl)-acetonitrile With potassium hydroxide in ethylene glycol T=130°C; 2.5 h; 2: With hydrogenchloride in water; ethylene glycol 3: methyl iodide With potassium carbonate in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
SANKYO COMPANY, LIMITED
Patent: WO2006/109633 A1, 2006 ;
Location in patent: Page/Page column 165-166 ;
反应条件
1: 2-(4-biphenylyl)-5-phenyl-oxazole; N-bromosuccinmide / tetrachloromethane / 15 h / 80 °C / |Inert atmosphere 2: tetrabutylammomium bromide / dichloromethane; water / 15 h / 20 °C 3: thionyl chloride / 15 h / 0 - 20 °C View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
