3-丁基二氢呋喃-2(3H)-酮合成路线 （共 8 条）
反应条件
1: With titanium tetrachloride in dichloromethane
T=-60 - -20°C;
2: With toluene-4-sulfonic acid in dichloromethane
T=20°C;
参考文献
Maslak, Veselin; Matovic, Radomir; Saicic, Radomir N.
Tetrahedron, 2004 , vol. 60, # 40 p. 8957 - 8966
反应条件
1: With titanium tetrachloride in hexane; dichloromethane
T=-60 - 20°C;
2: With toluene-4-sulfonic acid in hexane; dichloromethane
T=20°C; 3 h;
参考文献
Maslak, Veselin; Matovic, Radomir; Saicic, Radomir N.
Tetrahedron, 2004 , vol. 60, # 40 p. 8957 - 8966
反应条件
dihydrogen peroxide; sodium hydroxide in hexane; water
T=0°C; 24 h;
参考文献
Khafizova; Khusainova; Tyumkina; Dzhemilev
Russian Journal of Organic Chemistry, 2012 , vol. 48, # 6 p. 761 - 766
Zh. Org. Khim., 2012 , vol. 48, # 6 p. 765 - 770
反应条件
1.1: 60 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C
2.1: TiCl4 / CH2Cl2; hexane / -60 - 20 °C
2.2: 69 percent / p-TsOH / CH2Cl2; hexane / 3 h / 20 °C
View Scheme
参考文献
Maslak, Veselin; Matovic, Radomir; Saicic, Radomir N.
Tetrahedron, 2004 , vol. 60, # 40 p. 8957 - 8966
反应条件
1.1: 95 percent / LDA / tetrahydrofuran / -78 °C
2.1: TiCl4 / CH2Cl2; hexane / -60 - 20 °C
2.2: 80 percent / p-TsOH / CH2Cl2; hexane / 3 h / 20 °C
View Scheme
参考文献
Maslak, Veselin; Matovic, Radomir; Saicic, Radomir N.
Tetrahedron, 2004 , vol. 60, # 40 p. 8957 - 8966
反应条件
potassium hydroxide; ethanol
T=-15°C; Erhitzen des Reaktionsprodukts unter vermindertem Druck;
参考文献
Rothstein
Bulletin de la Societe Chimique de France, 1935 , vol. <5> 2, p. 80,85
反应条件
18-crown-6 ether
1.) THF, RT, 15 min, 2.) THF, RT, 3 h; Yield given. Multistep reaction;
参考文献
Jedlinski, Zbigniew; Kowalczuk, Marek; Kurcok, Piotr; Grzegorzek, Miroslaw; Ermel, Jolanta
Journal of Organic Chemistry, 1987 , vol. 52, # 20 p. 4601 - 4602
反应条件
hydrogenchloride; n-butyllithium
1.) -78 deg C, THF, 30 min; upto room temp. 5 h; 2.) reflux, 1.5 h; Yield given. Multistep reaction;
参考文献
Francotte, Eric; Lohmann, Dieter
Helvetica Chimica Acta, 1987 , vol. 70, p. 1569 - 1582
