2-氯-6-甲基-异烟酸肼合成路线 （共 4 条）
反应条件
1,1'-carbonyldiimidazole; hydrazine in tetrahydrofuran T=20°C;
参考文献
LUPIN LIMITED; IRLAPATI, Nageswara, Rao; SHAIKH, Zubair, Abdul Wajid; KARCHE, Vijay, Pandurang; DESHMUKH, Gokul, Keruji; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar
Patent: WO2013/164769 A1, 2013 ;
反应条件
methanol; hydrazine hydrate
参考文献
Maruyama; Imamura
Takeda Kenkyusho Nenpo, 1953 , vol. 12, p. 62,64
Chem.Abstr., 1954 , p. 4695
Full Text Show Details
Isler et al.
Helvetica Chimica Acta, 1955 , vol. 38, p. 1046,1058
反应条件
1: POCl3; PCl5 / Behandeln des Reaktionsprodukts mit Methanol 2: methanol; N2H4+H2O View Scheme
参考文献
Isler et al.
Helvetica Chimica Acta, 1955 , vol. 38, p. 1046,1058
反应条件
sodium hydroxide; palladium
Hydrogenation;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2005/80386 A1, 2005 ;
Location in patent: Page/Page column 68-69 ;
WO 2005/080386 A1
