N-[(1R,2R)-2-羟基-2-苯基-1-(1-吡咯烷甲基)乙基]-癸酰胺合成路线 （共 5 条）
反应条件
benzotriazol-1-ol in pyridine
参考文献
Mitchell, Scott A.; Oates, Bryan D.; Razavi, Hossein; Polt, Robin
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8837 - 8842
反应条件
1: 80.7 percent / aq. KOH / methanol / 16 h / 70 °C 2: 74.2 percent / 1-hydroxybenzotriazole / pyridine View Scheme
参考文献
Mitchell, Scott A.; Oates, Bryan D.; Razavi, Hossein; Polt, Robin
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8837 - 8842
反应条件
1: 98.5 percent / pyridine / 4 h / Ambient temperature 2: 70.1 percent / tetrahydrofuran / 11 h / Heating 3: 80.7 percent / aq. KOH / methanol / 16 h / 70 °C 4: 74.2 percent / 1-hydroxybenzotriazole / pyridine View Scheme
参考文献
Mitchell, Scott A.; Oates, Bryan D.; Razavi, Hossein; Polt, Robin
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8837 - 8842
反应条件
1: 72.8 percent / Et3N / CH2Cl2 / 5 h / 0 °C 2: 95 percent / aq. HF / acetonitrile / 1.25 h / Ambient temperature 3: 98.5 percent / pyridine / 4 h / Ambient temperature 4: 70.1 percent / tetrahydrofuran / 11 h / Heating 5: 80.7 percent / aq. KOH / methanol / 16 h / 70 °C 6: 74.2 percent / 1-hydroxybenzotriazole / pyridine View Scheme
参考文献
Mitchell, Scott A.; Oates, Bryan D.; Razavi, Hossein; Polt, Robin
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8837 - 8842
反应条件
1: 95 percent / aq. HF / acetonitrile / 1.25 h / Ambient temperature 2: 98.5 percent / pyridine / 4 h / Ambient temperature 3: 70.1 percent / tetrahydrofuran / 11 h / Heating 4: 80.7 percent / aq. KOH / methanol / 16 h / 70 °C 5: 74.2 percent / 1-hydroxybenzotriazole / pyridine View Scheme
参考文献
Mitchell, Scott A.; Oates, Bryan D.; Razavi, Hossein; Polt, Robin
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8837 - 8842
