1-甲基-3-羟基-2(1H)-吡啶酮合成路线 （共 12 条）
反应条件
palladium 10 on activated carbon in methanol T=20°C; P=760.051 Torr; 5 h;
参考文献
Genentech, Inc.
Patent: US2012/214762 A1, 2012 ;
Location in patent: Page/Page column 94 ;
反应条件
1: T=150°C; 48 - 60 h; 2: With sodium sulfite in water
参考文献
ALGETA ASA; Ramdahl, Thomas
Patent: US2013/183235 A1, 2013 ;
Location in patent: Paragraph 0205 ;
反应条件
boron tribromide in dichloromethane T=-30 - 20°C; 48 h; Inert atmosphere;
参考文献
Patil, Vishal; Sodji, Quaovi H.; Kornacki, James R.; Mrksich, Milan; Oyelere, Adegboyega K.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3492 - 3506
反应条件
in water; methyl iodide
反应条件
1: 53.4 percent / KOH / methanol / 2.5 h / 20 - 40 °C 2: 1.) KOH / 1.) DMSO, 10 min, 2.) DMSO, 2 h 3: 3.7 g / H2 / Pd/C / methanol / 1 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 22, # 10 p. 2277 - 2283
反应条件
1: 1.) KOH / 1.) DMSO, 10 min, 2.) DMSO, 2 h 2: 3.7 g / H2 / Pd/C / methanol / 1 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 22, # 10 p. 2277 - 2283
反应条件
1: potasium hydroxide / propan-1-ol 2: 63 percent / boron tribromide / CH2Cl2 / 24 h / -70 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 19 p. 3659 - 3670
反应条件
T=130 - 140°C; 24 h;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 37, # 10 p. 1099 - 1102
反应条件
1: With potassium hydroxide 2: With boron tribromide
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 60, # 4 p. 508 - 512
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 65, p. 65,82
