1.1: BuLi / tetrahydrofuran / 0.17 h / -30 °C 1.2: 87 percent / tetrahydrofuran / 2 h / 0 °C 2.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C 2.2: TiCl4 / CH2Cl2 / 3 h / 0 °C 3.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 4.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 5.1: 148 mg / H2 / Pd/C / methanol / 1.5 h 6.1: Na2CO3 / dioxane; H2O / 2 h / 20 °C View Scheme

1: 148 mg / H2 / Pd/C / methanol / 1.5 h 2: Na2CO3 / dioxane; H2O / 2 h / 20 °C View Scheme

1.1: TiCl4; Et3N / CH2Cl2 / 0.5 h / -15 °C 1.2: TiCl4 / CH2Cl2 / 3 h / 0 °C 2.1: 80 percent / NaH; Bu4NI / dimethylformamide / 3 h / 70 °C 3.1: 85 percent / H2O2; LiOH*H2O / tetrahydrofuran; H2O / 4 h / 0 °C 4.1: 148 mg / H2 / Pd/C / methanol / 1.5 h 5.1: Na2CO3 / dioxane; H2O / 2 h / 20 °C View Scheme

sodium carbonate in 1,4-dioxane; water T=20°C; 2 h;