(S)-1-N-Cbz-3-氰基吡咯烷合成路线 （共 11 条）
反应条件
in dimethyl sulfoxide T=80°C; 21 h; Inert atmosphere;
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
Location in patent: Page/Page column 58-59 ;
反应条件
in dimethyl sulfoxide T=80°C; 4 h;
参考文献
Klein, Scott I.; Czekaj, Mark; Molino, Bruce F.; Valeria, Chu
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1773 - 1778
反应条件
1: tetrahydrofuran / -25 - 0 °C 2: 2.1 g / Bu4NCN / dimethylsulfoxide / 20 h / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 8 p. 1873 - 1881
反应条件
ethylenediaminetetraacetic acid in phosphate buffer T=30°C; pH=8.00; 18 h; Title compound not separated from byproducts.;
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 8-9 p. 1475 - 1480
反应条件
n-Bu4N+CN- in dimethyl sulfoxide T=60°C; 20 h;
参考文献
Dermatakis, Apos; Luk, Kin-Chun; DePinto, Wanda
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1873 - 1881
反应条件
1: Et3N / CH2Cl2 / 2 h / 0 °C 2: 1.00 g / Et3N; DMAP / CH2Cl2 / 3 h / 0 °C 3: 70 percent / dimethylsulfoxide / 4 h / 90 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 9 p. 1498 - 1502
反应条件
1: 57 percent / H2O2; Na2CO3 / acetone; H2O / 18 h / 20 °C 2: H2 / Pd/C / ethanol / 3 h / 760 Torr View Scheme
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
反应条件
hydrogenchloride; acetic acid 3 - 4 h; Heating / reflux; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/40192 A1, 2006 ;
Location in patent: Page/Page column 23 ;
WO 2006/040192 A1
反应条件
1: (+)-(S)-3-cyanopyrrolidine-1-carboxylic acid benzyl ester With hydrogenchloride; water 4.5 h; Reflux; 2: benzyl chloroformate With sodium carbonate in water; acetone T=0 - 20°C; 7 h; 3: With hydrogenchloride; potassium hydrogensulfate in water pH=2;
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
Location in patent: Page/Page column 62 ;
反应条件
hydrogenchloride in methanol; water 72 h; Ambient temperature;
参考文献
Klein, Scott I.; Czekaj, Mark; Molino, Bruce F.; Valeria, Chu
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1773 - 1778
