2-苯基-2,3-二氢-1H-异吲哚合成路线 （共 25 条）
反应条件
1: 100 percent / acetonitrile
2: 12 percent / aq. KOH / 30 - 95 °C
View Scheme
参考文献
Chukhadzhyan, E. O.; Manasyan, L. A.; Chukhadzhyan, El. O.; Shakhatuni, K. G.; Babayan, A. T.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1995 , vol. 31, # 1 p. 58 - 62
Khimiya Geterotsiklicheskikh Soedinenii, 1995 , # 1 p. 68 - 72
反应条件
1.1: methanol / 2 h / 20 °C / |Inert atmosphere
2.1: sodium tetrahydroborate / methanol / 1 h / |Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / 0 °C / |Inert atmosphere
3.2: 1 h / 0 °C / |Inert atmosphere
3.3: 2 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Jeffrey, Jenna L.; Bartlett, Emily S.; Sarpong, Richmond
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2194 - 2197
Angew. Chem., 2013 , vol. 125, # 8 p. 2250 - 2253,4
反应条件
1.1: methanol / 2 h / 20 °C / |Inert atmosphere
2.1: sodium tetrahydroborate / methanol / 1 h / |Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / 0 °C / |Inert atmosphere
3.2: 1 h / 0 °C / |Inert atmosphere
3.3: 2 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Jeffrey, Jenna L.; Bartlett, Emily S.; Sarpong, Richmond
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2194 - 2197
Angew. Chem., 2013 , vol. 125, # 8 p. 2250 - 2253,4
反应条件
1.1: sodium tetrahydroborate / methanol / 1 h / |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / 0 °C / |Inert atmosphere
2.2: 1 h / 0 °C / |Inert atmosphere
2.3: 2 h / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Jeffrey, Jenna L.; Bartlett, Emily S.; Sarpong, Richmond
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2194 - 2197
Angew. Chem., 2013 , vol. 125, # 8 p. 2250 - 2253,4
参考文献
Sommers
Journal of the American Chemical Society, 1956 , vol. 78, p. 2439,2445
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Wittig et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 594, p. 89,111
反应条件
nickel; butan-1-ol
Hydrogenation;
参考文献
Wittig et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 594, p. 89,111
反应条件
1: potassium amide; liquid ammonia
2: Raney nickel; butan-1-ol / Hydrogenation
View Scheme
参考文献
Wittig et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 594, p. 89,111
反应条件
1: aqueous hydrobromic acid; chloroform / Behandeln einer heissen Loesung des Reaktionsprodukts in wss. Ammoniak mit Kaliumjodid
2: potassium amide; liquid ammonia
3: Raney nickel; butan-1-ol / Hydrogenation
View Scheme
参考文献
Wittig et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 594, p. 89,111
反应条件
1: aqueous hydrobromic acid; chloroform / Behandeln einer heissen Loesung des Reaktionsprodukts in wss. Ammoniak mit Kaliumjodid
2: potassium amide; liquid ammonia
3: Raney nickel; butan-1-ol / Hydrogenation
View Scheme
参考文献
Wittig et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 594, p. 89,111
