1-(N-Boc-氨基)-3-环戊烯合成路线 （共 11 条）
反应条件
lithium hydroxide; water in tetrahydrofuran T=0°C; 3 h;
参考文献
NORTHWESTERN UNIVERSITY
Patent: WO2008/42353 A1, 2008 ;
Location in patent: Page/Page column 24 ;
反应条件
diphenylphosphoranyl azide; triethylamine; Copper(I)chloride in dichloromethane; tert-butyl alcohol
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=0 - 20°C; 50 h;
参考文献
Ji, Haitao; Stanton, Benjamin Z.; Igarashi, Jotaro; Li, Huiying; Martasek, Pavel; Roman, Linda J.; Poulos, Thomas L.; Silverman, Richard B.
Journal of the American Chemical Society, 2008 , vol. 130, # 12 p. 3900 - 3914
反应条件
1: 3-cyclopentene-1-carboxylic acid With diphenylphosphoranyl azide; triethylamine in toluene 7 h; Heating / reflux; 2: tert-butyl alcohol in toluene T=20°C; 16 h; Heating / reflux;
参考文献
US2004/87601 A1, ;
Page 14 ;
US 20040087601 A1
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C;
参考文献
O'Brien, Peter; Towers, Timothy D.; Voith, Matthias
Tetrahedron Letters, 1998 , vol. 39, # 44 p. 8175 - 8178
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; Acylation; 16 h;
参考文献
Barrett, Stephen; O'Brien, Peter; Steffens, H.Christian; Towers, Timothy D; Voith, Matthias
Tetrahedron, 2000 , vol. 56, # 49 p. 9633 - 9640
反应条件
2,6-di-tert-butyl-pyridine; zinc trifluoromethanesulfonate in acetonitrile T=85°C; 16 h;
参考文献
Stafford, Jeffrey A.; Gonzales, Stephen S.; Barrett, David G.; Suh, Edward M.; Feldman, Paul L.
Journal of Organic Chemistry, 1998 , vol. 63, # 26 p. 10040 - 10044
反应条件
1: Et3N / CH2Cl2 / 0.5 h / 0 °C 2: NaN3 / dimethylformamide / 16 h / 80 °C 3: 3.6 g / PPh3; water; aq. HCl / tetrahydrofuran; CH2Cl2 / 16 h / Heating 4: 77 percent / Et3N; DMAP / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 49 p. 9633 - 9640
反应条件
1: NaN3 / dimethylformamide / 16 h / 80 °C 2: 3.6 g / PPh3; water; aq. HCl / tetrahydrofuran; CH2Cl2 / 16 h / Heating 3: 77 percent / Et3N; DMAP / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 49 p. 9633 - 9640
反应条件
tin(IV) chloride Addition; 1 h; Heating;
参考文献
Hodgson, David M.; Thompson, Alison J.; Wadman, Sjoerd; Keats, Clare J.
Tetrahedron, 1999 , vol. 55, # 35 p. 10815 - 10834
