N-(2,3-二氢-1H-茚-2-基)-2,2,2-三氟乙酰胺合成路线 （共 10 条）
反应条件
triethylamine in tetrahydrofuran T=5 - 20°C; 0.5 h;
参考文献
WARNER-LAMBERT COMPANY LLC?
Patent: WO2005/56540 A1, 2005 ;
Location in patent: Page/Page column 36-37 ;
反应条件
triethylamine in tetrahydrofuran T=-75 - 20°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/133459 A1, 2006 ;
Location in patent: Page/Page column 50 ;
WO 2006/133459 A1
反应条件
in n-heptane; isopropanol acetate
参考文献
Prashad, Mahavir; Hu, Bin; Har, Denis; Repic, Oljan; Blacklock, Thomas J.; Lohse, Olivier
Organic Process Research and Development, 2006 , vol. 10, # 1 p. 135 - 141
反应条件
in ethyl acetate Ambient temperature;
参考文献
Mitrochkine, Anton A.; Blain, Ingrid; Bit, Christelle; Canlet, Cecile; Pierre, Sebastien; Courtieu, Jacques; Reglier, Marius
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6204 - 6209
反应条件
1.1: AlCl3, aluminium chloride / neat (no solvent) / 0.25 h / 0 - 5 °C 1.2: 255 / 1 h / 0 - 10 °C 2.1: hydrogen; 5 palladium on charcoal / ethanol; water / 25 °C / 2250.23 Torr / |Inert atmosphere 3.1: AlCl3, aluminium chloride / dichloromethane / 0.75 h / 0 °C 3.2: 1 h / 0 - 5 °C 4.1: palladium 10 on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / |Inert atmosphere 5.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / |Inert atmosphere 6.1: hydrogenchloride / isopropanol acetate / 2.67 h / 20 - 25 °C View Scheme
参考文献
Prashad, Mahavir; Hu, Bin; Har, Denis; Repic, Oljan; Blacklock, Thomas J.; Lohse, Olivier
Organic Process Research and Development, 2006 , vol. 10, # 1 p. 135 - 141
反应条件
1.1: AlCl3, aluminium chloride / neat (no solvent) / 0.25 h / 0 - 5 °C 1.2: 255 / 1 h / 0 - 10 °C 2.1: hydrogen; 5 palladium on charcoal / ethanol; water / 25 °C / 2250.23 Torr / |Inert atmosphere 3.1: AlCl3, aluminium chloride / dichloromethane / 0.75 h / 0 °C 3.2: 1 h / 0 - 5 °C 4.1: palladium 10 on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / |Inert atmosphere 5.1: sodium hydroxide / ethanol / 1.5 h / 78 °C / |Inert atmosphere View Scheme
参考文献
Prashad, Mahavir; Hu, Bin; Har, Denis; Repic, Oljan; Blacklock, Thomas J.; Lohse, Olivier
Organic Process Research and Development, 2006 , vol. 10, # 1 p. 135 - 141
反应条件
1: acetyl chloride With AlCl3, aluminium chloride in neat (no solvent)
T=0 - 5°C; Friedel-Crafts Acylation; 0.25 h;
2: N-(2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide in neat (no solvent)
T=0 - 10°C; Friedel-Crafts Acylation; 1 h; ConcentrationSolvent; regioselective reaction;
参考文献
Prashad, Mahavir; Hu, Bin; Har, Denis; Repic, Oljan; Blacklock, Thomas J.; Lohse, Olivier
Organic Process Research and Development, 2006 , vol. 10, # 1 p. 135 - 141
反应条件
1.1: AlCl3, aluminium chloride / neat (no solvent) / 0.25 h / 0 - 5 °C
1.2: 255 / 1 h / 0 - 10 °C
2.1: hydrogen; 5 palladium on charcoal / ethanol; water / 25 °C / 2250.23 Torr / |Inert atmosphere
View Scheme
参考文献
Prashad, Mahavir; Hu, Bin; Har, Denis; Repic, Oljan; Blacklock, Thomas J.; Lohse, Olivier
Organic Process Research and Development, 2006 , vol. 10, # 1 p. 135 - 141
反应条件
1.1: AlCl3, aluminium chloride / neat (no solvent) / 0.25 h / 0 - 5 °C
1.2: 255 / 1 h / 0 - 10 °C
2.1: hydrogen; 5 palladium on charcoal / ethanol; water / 25 °C / 2250.23 Torr / |Inert atmosphere
3.1: AlCl3, aluminium chloride / dichloromethane / 0.75 h / 0 °C
3.2: 1 h / 0 - 5 °C
View Scheme
参考文献
Prashad, Mahavir; Hu, Bin; Har, Denis; Repic, Oljan; Blacklock, Thomas J.; Lohse, Olivier
Organic Process Research and Development, 2006 , vol. 10, # 1 p. 135 - 141
反应条件
1.1: AlCl3, aluminium chloride / neat (no solvent) / 0.25 h / 0 - 5 °C
1.2: 255 / 1 h / 0 - 10 °C
2.1: hydrogen; 5 palladium on charcoal / ethanol; water / 25 °C / 2250.23 Torr / |Inert atmosphere
3.1: AlCl3, aluminium chloride / dichloromethane / 0.75 h / 0 °C
3.2: 1 h / 0 - 5 °C
4.1: palladium 10 on activated carbon / water; ethyl acetate / 0.17 h / 25 °C / 2828.7 Torr / |Inert atmosphere
View Scheme
参考文献
Prashad, Mahavir; Hu, Bin; Har, Denis; Repic, Oljan; Blacklock, Thomas J.; Lohse, Olivier
Organic Process Research and Development, 2006 , vol. 10, # 1 p. 135 - 141
