1-Boc-4-(5-硝基-2-吡啶基)哌嗪合成路线 （共 8 条）
反应条件
potassium carbonate; tetra-(n-butyl)ammonium iodide in dimethyl sulfoxide T=50°C; 3 h;
参考文献
WARNER-LAMBERT COMPANY, LLC
Patent: US2005/182078 A1, 2005 ;
Location in patent: Page/Page column 9; 12 ;
US 20050182078 A1
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=100°C; 16 h;
参考文献
Ting, Pauline C.; Lee, Joe F.; Zorn, Nicolas; Kim, Hyunjin M.; Aslanian, Robert G.; Lin, Mingxiang; Smith, Michelle; Walker, Scott S.; Cook, John; Van Heek, Margaret; Lachowicz, Jean
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 985 - 988
参考文献
Liu, Yu; Liu, Zining; Cao, Xufeng; Liu, Xin; He, Huili; Yang, Yushe
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4779 - 4783
反应条件
1: With trifluoroacetic acid in dichloromethane T=0 - 20°C; 16 h; 2: With sodium hydroxide in dichloromethane; water
参考文献
Ting, Pauline C.; Lee, Joe F.; Zorn, Nicolas; Kim, Hyunjin M.; Aslanian, Robert G.; Lin, Mingxiang; Smith, Michelle; Walker, Scott S.; Cook, John; Van Heek, Margaret; Lachowicz, Jean
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 985 - 988
反应条件
hydrogen; nickel in tetrahydrofuran P=2585.81 Torr; 5 h;
参考文献
WARNER-LAMBERT COMPANY, LLC
Patent: US2005/182078 A1, 2005 ;
Location in patent: Page/Page column 9; 12 ;
US 20050182078 A1
反应条件
hydrogenchloride in methanol; dichloromethane 24 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/32667 A1, 2009 ;
Location in patent: Page/Page column 150 ;
WO 2009/032667 A1
反应条件
1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere 1.2: 20 °C 2.1: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 0.5 h / 70 °C / 750.08 Torr / H-Cube.(TM). View Scheme
参考文献
Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.
Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909
反应条件
1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere
1.2: 20 °C
2.1: polymer-supported N-methylmorpholine / dichloromethane / 16 h
3.1: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 0.5 h / 70 °C / 750.08 Torr / H-Cube.(TM).
View Scheme
参考文献
Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.
Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909
