4-(4-Boc-哌嗪-1-基)-3-氯苯胺合成路线 （共 4 条）
反应条件
1: With acetic acid; zinc in tetrahydrofuran; methanol T=20°C; 1 h; 2: With sodium hydrogencarbonate in tetrahydrofuran; methanol; water 1 h;
参考文献
Sankyo Company, Limited
Patent: EP1764360 A1, 2007 ;
Location in patent: Page/Page column 161 ;
EP 1764360 A1
反应条件
1: N,N-diisopropylethylamine / acetonitrile / 14 h / Heating 2: H2 / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr View Scheme
参考文献
VanderWel, Scott N.; Harvey, Patricia J.; McNamara, Dennis J.; Repine, Joseph T.; Keller, Paul R.; Quin III, John; Booth, R. John; Elliott, William L.; Dobrusin, Ellen M.; Fry, David W.; Toogood, Peter L.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2371 - 2387
反应条件
1: N,N-diisopropylethylamine / acetonitrile / 14 h / Heating 2: H2 / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr View Scheme
参考文献
VanderWel, Scott N.; Harvey, Patricia J.; McNamara, Dennis J.; Repine, Joseph T.; Keller, Paul R.; Quin III, John; Booth, R. John; Elliott, William L.; Dobrusin, Ellen M.; Fry, David W.; Toogood, Peter L.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2371 - 2387
反应条件
1: potassium carbonate / tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 125 °C 2: zinc; acetic acid / tetrahydrofuran; methanol / 1 h / 20 °C View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; WU, Fengchun; SHEN, Yan; LIU, Cuihua; ZOU, Zhenguang
Patent: WO2012/97684 A1, 2012 ;
WO 2012/097684 A1
