苏式-苯基哌啶-2-乙酰胺合成路线 （共 4 条）
反应条件
hydrogen; acetic acid; 5 rhodium-on-charcoal T=50 - 55°C; P=11251.1 Torr; 5 - 6 h;
参考文献
WO2006/64052 A1, ;
Page/Page column 4 ;
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=45°C; P=7355.72 Torr; 10 h;
参考文献
Chavan, Anil B.; Gundecha, Sachin S.; Kadam, Pramod N.; Maikap, Golak C.; Gurjar, Mukund K.
Organic Process Research and Development, 2010 , vol. 14, # 6 p. 1473 - 1475
反应条件
1: With L-(+)-tartaric acid in ethanol; water T=20°C; 18 h; Resolution of racemate; 2: in water pH=13; Product distribution / selectivity;
参考文献
CELGENE CORPORATION
Patent: EP1082307 B1, 2005 ;
Location in patent: Page/Page column 5-6 ;
反应条件
hydrogenchloride; potassium hydroxide 1.) reflux, 6 h, 2.) reflux, 4 d; Multistep reaction;
参考文献
Deutsch, Howard M.; Shi, Qing; Gruszecka-Kowalik, Ewa; Schwer, Margaret M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1201 - 1209
