1-溴-4-(三异丙基甲硅烷基氧基)苯合成路线 （共 7 条）
反应条件
1H-imidazole in DMF (N,N-dimethyl-formamide) T=20°C; 4 h;
参考文献
Mortensen, Deborah S.; Perrin-Ninkovic, Sophie M.; Harris, Roy; Lee, Branden G.S.; Shevlin, Graziella; Hickman, Matt; Khambatta, Gody; Bisonette, Rene R.; Fultz, Kimberly E.; Sankar, Sabita
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6793 - 6799
反应条件
2,6-dimethylpyridine in dichloromethane T=0°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1911738 A1, 2008 ;
Location in patent: Page/Page column 35 ;
反应条件
in water; N,N-dimethyl-formamide
参考文献
Eli Lilly and Company
Patent: US6284756 B1, 2001 ;
US 6284756 B1
反应条件
in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
Scanlan, Thomas S.; Hart, Matthew E.; Grandy, David K.; Bunzow, James R.; Miyakawa, Mononori; Tan, Edwin Saavedra; Suchland, Katherine L.
Patent: US2005/96485 A1, 2005 ;
反应条件
potassium acetate in water; N,N-dimethyl-formamide T=25°C; 5 h;
参考文献
Green Chemistry, , vol. 11, # 8 p. 1112 - 1114
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: triisopropyl borate / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
1.3: 68 percent / aq. HCl / tetrahydrofuran; hexane / 0.5 h / 0 °C
2.1: 36 percent / Cu(OAc)2; Et3N; pyridine / 4 Angstroem molecular sieves / CH2Cl2 / 20 °C
View Scheme
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: triisopropyl borate / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
1.3: 68 percent / aq. HCl / tetrahydrofuran; hexane / 0.5 h / 0 °C
2.1: 40 percent / Cu(OAc)2; Et3N; pyridine / 4 Angstroem molecular sieves / CH2Cl2 / 20 °C
3.1: 86 percent / TBAF / tetrahydrofuran / 0 °C
4.1: 100 percent / HCl / ethyl acetate / 20 °C
View Scheme
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
