乙基[6-甲基-2-(4-甲基苯基)咪唑并[1,2-a]吡啶-3-基]乙酸酯合成路线 （共 10 条）
反应条件
water; potassium hydroxide in ethanol T=30°C;
参考文献
Nair, Divya K.; Mobin, Shaikh M.; Namboothiri, Irishi N.N.
Organic Letters, 2012 , vol. 14, # 17 p. 4580 - 4583
反应条件
in ethanol T=20°C; 168 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR RT.
Patent: EP1259509 B1, 2005 ;
Location in patent: Page/Page column 10 ;
反应条件
1: water; potassium hydroxide / ethanol / 30 °C 2: phosphorus pentachloride / dichloromethane / |Reflux 3: dichloromethane / 0.5 h / 0 °C View Scheme
参考文献
Nair, Divya K.; Mobin, Shaikh M.; Namboothiri, Irishi N.N.
Organic Letters, 2012 , vol. 14, # 17 p. 4580 - 4583
反应条件
in methanol
T=30°C; 0.333333 h; regioselective reaction;
参考文献
Nair, Divya K.; Mobin, Shaikh M.; Namboothiri, Irishi N.N.
Organic Letters, 2012 , vol. 14, # 17 p. 4580 - 4583
反应条件
1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 30 °C
2: pyridine / dichloromethane / 0.5 h / 0 °C
3: methanol / 0.33 h / 30 °C
View Scheme
参考文献
Nair, Divya K.; Mobin, Shaikh M.; Namboothiri, Irishi N.N.
Organic Letters, 2012 , vol. 14, # 17 p. 4580 - 4583
反应条件
1: Br2, AcOH
2: 10 percent / butan-1-ol / Heating
View Scheme
参考文献
Trapani, Giuseppe; Franco, Massimo; Ricciardi, Laura; Latrofa, Andrea; Genchi, Giuseppe; Sanna, Enrico; Tuveri, Francesca; Cagetti, Elisabetta; Biggio, Giovanni; Liso, Gaetano
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3109 - 3118
反应条件
copper(II) bis(trifluoromethanesulfonate); copper(l) chloride in toluene
T=25°C; 1 h; Inert atmosphereMolecular sieve;
参考文献
Chernyak, Natalia; Gevorgyan, Vladimir
Angewandte Chemie - International Edition, 2010 , vol. 49, # 15 p. 2743 - 2746
反应条件
tetrafluoroboric acid diethyl ether complex in acetonitrile
T=120°C; Flow reactor;
参考文献
Guetzoyan, Lucie; Nikbin, Nikzad; Baxendale, Ian R.; Ley, Steven V.
Chemical Science, 2013 , vol. 4, # 2 p. 764 - 769
反应条件
in butan-1-ol
Heating;
参考文献
Trapani, Giuseppe; Franco, Massimo; Ricciardi, Laura; Latrofa, Andrea; Genchi, Giuseppe; Sanna, Enrico; Tuveri, Francesca; Cagetti, Elisabetta; Biggio, Giovanni; Liso, Gaetano
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3109 - 3118
反应条件
1: polymer supported sulfonic acid resin / toluene / 120 °C / |Flow reactor
2: tetrafluoroboric acid diethyl ether complex / acetonitrile / 120 °C / |Flow reactor
View Scheme
参考文献
Guetzoyan, Lucie; Nikbin, Nikzad; Baxendale, Ian R.; Ley, Steven V.
Chemical Science, 2013 , vol. 4, # 2 p. 764 - 769
