2-氯甲基-4-氟-1-甲氧基苯合成路线 （共 5 条）
反应条件
1: 54 percent / hexamethylenetetramine, aq. HOAc / 2 h / Heating 2: 96.6 percent / piperidine / pyridine / 1) room temperature, 16 h; 2) 60 deg C, 4 h; 3) 100 deg C, 3 h View Scheme
参考文献
Vallaerda, Jerk; Appelberg, Ulf; Csoeregh, Ingeborg; Hacksell, Uli
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 4 p. 461 - 470
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; acetic acid 2 h; Heating;
参考文献
Vallaerda, Jerk; Appelberg, Ulf; Csoeregh, Ingeborg; Hacksell, Uli
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 4 p. 461 - 470
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 2 h;
参考文献
Bayer HealthCare AG
Patent: EP1216225 B1, 2005 ;
Location in patent: Page/Page column 39-40 ;
反应条件
hydrogenchloride; zinc(II) chloride in water
参考文献
Maziere,B.; Dat-Xuong,N.
Chimica Therapeutica, 1968 , vol. 3, p. 1 - 9
反应条件
hydrogenchloride; sulfuric acid
T=70°C; 3 h;
参考文献
Vallaerda, Jerk; Appelberg, Ulf; Csoeregh, Ingeborg; Hacksell, Uli
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 4 p. 461 - 470
