(2R)-2-羟基-3-[(9Z)-9-十八碳烯酰基氧基]丙基 2-(三甲基铵基)乙基磷酸酯合成路线 （共 3 条）
反应条件
1: L-alpha-glycerylphosphorylcholine With di(n-butyl)tin oxide in isopropyl alcohol 1 h; Heating / reflux; 2: oleic acid chloride With triethylamine in isopropyl alcohol T=0°C; 0.25 h;
参考文献
Chem SPA
Patent: US2006/79703 A1, 2006 ;
Location in patent: Page/Page column 3-4 ;
反应条件
1: L-alpha-glycerylphosphorylcholine With di(n-butyl)tin oxide in isopropyl alcohol 1 h; Heating / reflux; 2: oleic acid chloride With triethylamine in isopropyl alcohol T=0 - 20°C; 0.25 h;
参考文献
CHEMI S.p.A.
Patent: EP1650215 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
1: L-alpha-glycerylphosphorylcholine With di(n-butyl)tin oxide in isopropyl alcohol 1 h; Heating; 2: oleic acid chloride With TEA in isopropyl alcohol T=20°C; 0.583333 h; Further stages.;
参考文献
Fasoli, Ezio; Arnone, Alberto; Caligiuri, Antonio; D'Arrigo, Paola; De Ferra, Lorenzo; Servi, Stefano
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 15 p. 2974 - 2978
