1.1: tert-BuLi / tetrahydrofuran; pentane / 1.25 h / -78 - -20 °C 1.2: 82 percent / tetrahydrofuran; pentane / 0.5 h / -78 °C 2.1: 79 percent / sodium amalgam / methanol / 4 h / Heating View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2809675', constants.ctx, '0')">(1S)-10-camphorsulfonic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '969212', constants.ctx, '0')">benzene</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 95 percent / pyridine; tri-n-butylphosphine / 30 h / 20 &deg;C<br />2: 96 percent / MCPBA / CH₂Cl₂ / 24 h / 0 - 20 &deg;C<br />3: 100 percent / K₂CO₃ / methanol / 0.5 h / 20 &deg;C<br />4: 95 percent / hydrogen / Pd(OH)2-C / methanol / 2 h / 20 &deg;C<br />5: 87 percent / 10-camphorsulfonic acid / benzene / 24 h / 20 &deg;C<br /> <br /> &nbsp;