2-甲基噻吩-3-羧酸乙酯合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
反应条件
1: 3-bromo-2-methyl thiophene With magnesium; lithium chloride in tetrahydrofuran Reflux; 2: chloroformic acid ethyl ester in tetrahydrofuran T=-20 - 0°C; 2.66667 h; Inert atmosphere;
参考文献
Kogami, Masakazu; Watanabe, Nobuhide
Synthetic Communications, 2013 , vol. 43, # 5 p. 681 - 688
反应条件
2,3-dichloro-4,5-dicyanoquinone in dichloromethane T=40°C; 2 h;
参考文献
Chatterjee, Pallab; Murphy, Patrick J.; Pepe, Rosanna; Shaw, Michael
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2403 - 2406
反应条件
1: 3-bromo-2-methyl thiophene With magnesium; lithium chloride in tetrahydrofuran Reflux; 2: chloroformic acid ethyl ester in tetrahydrofuran T=-20 - 0°C; Inert atmosphere;
参考文献
Kogami, Masakazu; Watanabe, Nobuhide
Synthetic Communications, 2013 , vol. 43, # 5 p. 681 - 688
反应条件
1.1: N-bromosuccinmide; acetic acid / 5.92 h / 20 °C 2.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 6.5 h / 30 - 60 °C 2.2: 6 h / -5 - 5 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 59, # 6 p. 797 - 798
反应条件
sodium hydroxide in ethanol 2 h; Heating;
参考文献
Khalaf, Abedawn I.; Ebrahimabadi, Abdolrasoul H.; Drummond, Allan J.; Anthony, Nahoum G.; Mackay, Simon P.; Suckling, Colin J.; Waigh, Roger D.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 21 p. 3119 - 3127
