5-甲基噻吩-2-羧酸甲酯合成路线 （共 24 条）
反应条件
1.1: nitric acid; sulfuric acid / 0.5 h / 0 °C
2.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 36 h / 20 °C / 760.05 Torr
3.1: potassium acetate / toluene / 3 h / 100 °C
3.2: 100 °C
4.1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C
4.2: 0.5 h / 0 °C
View Scheme
参考文献
SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: US2012/245178 A1, 2012 ;
US 20120245178 A1
反应条件
1: nitric acid; sulfuric acid / 0.5 h / 0 °C
2: hydrogen / Raney Ni / tetrahydrofuran; methanol / 36 h / 20 °C / 760.05 Torr
View Scheme
参考文献
SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: US2012/245178 A1, 2012 ;
US 20120245178 A1
反应条件
sulfuric acid; nitric acid
T=0 - 5°C; 0.5 h;
参考文献
Japan Tobacco Inc.
Patent: EP1688420 A1, 2006 ;
Location in patent: Page/Page column 131 ;
反应条件
lithium aluminium tetrahydride in diethyl ether
Yield given;
参考文献
Lozanova, A. V.; Moiseenkov, A. M.; Semenovskii, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 4 p. 619 - 623
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 4 p. 838 - 842
