反应条件
1.1: 2,4,6-trimethyl-pyridine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0.5 h / 20 °C / Cooling with acetonitrile-dry ice
2.1: iron (III) acetylacetonate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.25 h / 20 °C
3.1: sodium hydroxide; ethanol; water / 0.5 h / 80 °C
3.2: 0 - 20 °C
View Scheme
参考文献
Brady, Ryan M.; Vom, Amelia; Roy, Michael J.; Toovey, Nathan; Smith, Brian J.; Moss, Rebecca M.; Hatzis, Effie; Huang, David C. S.; Parisot, John P.; Yang, Hong; Street, Ian P.; Colman, Peter M.; Czabotar, Peter E.; Baell, Jonathan B.; Lessene, Guillaume
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1323 - 1343