6,6-二甲基-3-氮杂双环[3.1.0]己烷-2,4-二酮合成路线 （共 4 条）
反应条件
urea T=160 - 170°C; Neat (no solvent);
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
Location in patent: Page/Page column 37 ;
WO 2012/049688 A1
反应条件
potassium tert-butylate in tert-butyl alcohol T=80 - 90°C; 18 h;
参考文献
Mackman, Richard L.; Micklefield, Jason; Block, Michael H.; Leeper, Finian J.; Battersby, Alan R.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 14 p. 2111 - 2122
反应条件
sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran
T=-30 - 50°C; Product distribution / selectivity;
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
Location in patent: Page/Page column 36 ;
WO 2012/049688 A1
反应条件
1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / -30 - 50 °C
2: hydrogenchloride / toluene / 0.5 h / 5 - 10 °C
View Scheme
参考文献
ARCH PHARMALABS LIMITED; SHINDE, Anant Dharma; CHAUDARI, Bapu Atmaram; PAI, Ganesh Gurpur; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SONAANE, Sachin Ulhas; SARJEKAR, Pushpalata Bakrishna
Patent: WO2012/49688 A1, 2012 ;
WO 2012/049688 A1
