N-[4-[(3-溴苯基)氨基]-6-喹唑啉]-2-丙酰胺合成路线 （共 8 条）
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide 4 h; Ambient temperature;
参考文献
Warner-Lambert Company
Patent: US6344459 B1, 2002 ;
Location in patent: Page column 48 ;
US 6344459 B1
反应条件
potassium tert-butylate in DMF (N,N-dimethyl-formamide) T=20°C; 5 h; Product distribution / selectivity;
参考文献
Wyeth
Patent: EP1100788 B1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=20°C; 1 h; Product distribution / selectivity;
参考文献
Wyeth
Patent: EP1100788 B1, 2005 ;
Location in patent: Page/Page column 9-10 ;
反应条件
potassium tert-butylate in DMF (N,N-dimethyl-formamide) T=20°C; 48 h; Product distribution / selectivity;
参考文献
Wyeth
Patent: EP1100788 B1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
N-ethyl-N,N-diisopropylamine
参考文献
Pawar, Vijaykumar G.; Sos, Martin L.; Rode, Haridas B.; Rabiller, Matthias; Heynck, Stefanie; Van Otterlo, Willem A. L.; Thomas, Roman K.; Rauh, Daniel
Journal of Medicinal Chemistry, 2010 , vol. 53, # 7 p. 2892 - 2901
参考文献
American Cyanamid Company
Patent: EP787722 A1, 1997 ;
Title/Abstract Full Text Show Details
Wyeth Holdings Corporation
Patent: EP980244 B1, 2003 ;
反应条件
1: 98 percent / 1.5 h / Heating 2: 89 percent / HOAc / 1 h / Heating 3: 89 percent / HOAc; Fe / ethanol / 3 h / Heating 4: 8.5 percent / pyridine / diethyl ether / 3.5 h / 20 °C View Scheme
参考文献
Tsou; Mamuya; Johnson; Reich; Gruber; Ye; Nilakantan; Shen; Discafani; DeBlanc; Davis; Koehn; Greenberger; Wang; Wissner
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2719 - 2734
反应条件
1: 89 percent / HOAc; Fe / ethanol / 3 h / Heating 2: 8.5 percent / pyridine / diethyl ether / 3.5 h / 20 °C View Scheme
参考文献
Tsou; Mamuya; Johnson; Reich; Gruber; Ye; Nilakantan; Shen; Discafani; DeBlanc; Davis; Koehn; Greenberger; Wang; Wissner
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2719 - 2734
