2-羟基-2-甲基丙酸苄酯合成路线 （共 6 条）
反应条件
tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate in dichloromethane T=20°C; 48 h;
参考文献
Murakami, Nobutoshi; Tamura, Satoru; Wang, Weiqi; Takagi, Tatsuya; Kobayashi, Motomasa
Tetrahedron, 2001 , vol. 57, # 20 p. 4323 - 4336
反应条件
1: 2-methyl-2-hydroxypropanoic acid With sodium hydride in tetrahydrofuran; mineral oil T=5 - 20°C; 1 h; 2: bromomethyl-cyclopropane With potassium iodide in N,N-dimethyl-formamide T=100°C; 3 h; Microwave irradiation;
参考文献
CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria
Patent: WO2013/45280 A1, 2013 ;
Location in patent: Page/Page column 266 ;
反应条件
phenyl silane; oxygen; bis(dipivaloylmethanato)manganese(II) in isopropyl alcohol T=0°C; P=760 Torr; 1.5 h;
参考文献
Inoki, Satoshi; Kato, Koji; Isayama, Shigeru; Mukaiyama, Teruaki
Chemistry Letters, 1990 , # 10 p. 1869 - 1872
反应条件
in N,N-dimethyl-formamide T=160°C;
参考文献
Kuz'michev,O.V. et al.
Journal of Organic Chemistry USSR (English Translation), 1968 , vol. 4, p. 445 - 448
Zhurnal Organicheskoi Khimii, 1968 , vol. 4, # 3 p. 455 - 459
反应条件
unter Abdestillieren des entstehenden Wassers;
参考文献
Am. Cyanamid Co.
Patent: US2336317 , 1940 ;
反应条件
phosphorus pentachloride in toluene T=80°C;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 4, p. 445 - 448
Zhurnal Organicheskoi Khimii, , vol. 4, # 3 p. 455 - 459
