(±)-α-羟基-γ-丁内酯合成路线 （共 32 条）
反应条件
water; tin(IV) chloride in 1,4-dioxane T=20 - 140°C; 3 h; AutoclaveInert atmosphere; Reagent/catalystConcentrationTemperatureTime;
参考文献
Chemical Communications, , vol. 50, # 35 p. 4600 - 4602
反应条件
phosphorus; bromine Erwaermen des von Brom befreiten Reaktionsgemisches mit Bariumhydroxid und Wasser und Erhitzen unter vermindertem Druck;
参考文献
Chemische Berichte, , vol. 69, p. 255,257
反应条件
Birman's catalyst; DPHAA; N-ethyl-N,N-diisopropylamine in diethyl ether T=20°C; 12 h; Inert atmosphere; enantioselective reaction;
参考文献
Nakata, Kenya; Gotoh, Kouya; Ono, Keisuke; Futami, Kengo; Shiina, Isamu
Organic Letters, 2013 , vol. 15, # 6 p. 1170 - 1173
反应条件
Birman's catalyst; N-ethyl-N,N-diisopropylamine in diethyl ether T=20°C; 12 h; Inert atmosphere; enantioselective reaction;
参考文献
Nakata, Kenya; Gotoh, Kouya; Ono, Keisuke; Futami, Kengo; Shiina, Isamu
Organic Letters, 2013 , vol. 15, # 6 p. 1170 - 1173
反应条件
(S)-(-)-BTM; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; 24 h; Molecular sieveInert atmosphere;
参考文献
Clark, Robert W.; Deaton, T. Maxwell; Zhang, Yan; Moore, Maggie I.; Wiskur, Sheryl L.
Organic Letters, 2013 , vol. 15, # 24 p. 6132 - 6135
反应条件
triethylamine in dichloromethane T=0 - 21°C; 5.5 h;
参考文献
Angell, Richard M.; Biggadike, Keith; Farrell, Rosanne M.; Flack, Stephen S.; Hancock, Ashley P.; Irving, Wendy R.; Lynn, Sean M.; Procopiou, Panayiotis A.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 6 p. 831 - 839
反应条件
sulfuric acid; acetic anhydride T=0°C; 0.25 h;
参考文献
Board of Trustees of Michigan State University
Patent: US2005/267307 A1, 2005 ;
Location in patent: Page/Page column 4 ;
反应条件
silver(l) oxide in chloroform 1 h; Heating;
参考文献
Capon, Robert J.; Vuong, Dat; Lacey, Ernest; Gill, Jennifer H.
Journal of Natural Products, 2005 , vol. 68, # 2 p. 179 - 182
反应条件
T=45 - 50°C; lactone of/the/ dextrorotatory α.γ-dioxy-butyric acid;
参考文献
Nef
Justus Liebigs Annalen der Chemie, 1910 , vol. 376, p. 73
反应条件
Birman's catalyst; DPHAA; N-ethyl-N,N-diisopropylamine in diethyl ether T=20°C; 12 h; Inert atmosphere; enantioselective reaction;
参考文献
Nakata, Kenya; Gotoh, Kouya; Ono, Keisuke; Futami, Kengo; Shiina, Isamu
Organic Letters, 2013 , vol. 15, # 6 p. 1170 - 1173
