5,6-二氯苯并咪唑-2-硫醇合成路线 （共 7 条）
反应条件
potassium hydroxide in ethanol; water 3 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 18 p. 2942 - 2949
反应条件
1: H2 / Raney Ni / ethanol / 4 h / Ambient temperature 2: 79 percent / aq. KOH / ethanol / 28.5 h / Heating View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 13, # 1-3 p. 437 - 446
反应条件
1: 46 percent / conc. HNO3, H2SO4, SO3 / 2 h / 100 °C 2: H2 / Raney Ni / ethanol / 4 h / Ambient temperature 3: 79 percent / aq. KOH / ethanol / 28.5 h / Heating View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 13, # 1-3 p. 437 - 446
反应条件
1: 1.) bis(trimethylsilyl)acetamide, 2.) TMSOTf / 1.) MeCN, 15 min, 2.) MeCN, 50 deg C, 18 h 2: 76 percent / methanol. NH3 / 18 h / Ambient temperature 3: 78 percent / aq. NH3 / acetonitrile / 18 h / Ambient temperature 4: 85 percent / Raney Ni / ethanol / 8 h / Heating View Scheme
参考文献
Devivar, Rodrigo V.; Kawashima, Etsuko; Revankar, Ganapathi R.; Breitenbach, Julie M.; Kreske, Edward D.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2942 - 2949
反应条件
dihydrogen peroxide in water 4 h; Heating;
参考文献
Hinkley, Jack M.; Porcari, Anthony R.; Walker II, John A.; Swayze, Eric E.; Townsend, Leroy B.
Synthetic Communications, 1998 , vol. 28, # 9 p. 1703 - 1712
反应条件
potassium hydroxide in ethanol; water T=20°C; 1 h;
参考文献
Valdez, Juan; Cedillo, Roberto; Hernandez-Campos, Alicia; Yepez, Lilian; Hernandez-Luis, Francisco; Navarrete-Vazquez, Gabriel; Tapia, Amparo; Cortes, Rafael; Hernandez, Manuel; Castillo, Rafael
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 16 p. 2221 - 2224
反应条件
1: 92 percent / NaCO3*1.5H2O2 / H2O / 4 h / Heating 2: 82 percent / PCl5 / POCl3 / 6 h / Heating View Scheme
参考文献
Hinkley, Jack M.; Porcari, Anthony R.; Walker II, John A.; Swayze, Eric E.; Townsend, Leroy B.
Synthetic Communications, 1998 , vol. 28, # 9 p. 1703 - 1712
