5-溴-2-(哌啶-4-基氧基)吡啶合成路线 （共 3 条）
反应条件
1: 4-hydroxy-piperidine With sodium hydride in dimethyl sulfoxide 0.5 h; 2: 2,5-dibromo-pyridine in dimethyl sulfoxide 48 h;
参考文献
PFIZER INC.
Patent: WO2006/21886 A1, 2006 ;
Location in patent: Page/Page column 84 ;
WO 2006/021886 A1
反应条件
sodium hydride in tetrahydrofuran; mineral oil T=20°C; 4 h;
参考文献
Guo, Bin; Fan, Houxing; Xin, Qisheng; Chu, Wenjing; Wang, Hui; Huang, Yanqin; Chen, Xiaoyan; Yang, Yushe
Journal of Medicinal Chemistry, 2013 , vol. 56, # 6 p. 2642 - 2650
参考文献
Zeneca Limited
Patent: US6313127 B1, 2001 ;
