反应条件
1: 2-(2'-bromophenyl)-acetonitrile With sodium hydride in Pionier 2076; N,N-dimethyl-formamide
T=0 - 23°C; 0.166667 h;
2: N-(2,2'-bischloro)diethyl-N-(1,1-dimethylethoxy)carbonyl amine in Pionier 2076; N,N-dimethyl-formamide
T=80°C;
3: With ammonium chloride in Pionier 2076; water; N,N-dimethyl-formamide
参考文献
SCHERING CORPORATION; BOGEN, Stephane, L.; MA, Yao; WANG, Yaolin; LAHUE, Brian Robert; NAIR, Latha, G.; SHIZUKA, Manami; VOSS, Matthew Ernst; KIROVA-SNOVER, Margarita; PAN, Weidong; TIAN, Yuan; KULKARNI, Bheemashankar, A.; GIBEAU, Craig, R.; LIU, Yuan; SCAPIN, Giovanna; RINDGEN, Diane; DOLL, Ronald, J.; GUZI, Timothy, J.; HICKLIN, Danny, J.; NOMEIR, Amin; SEIDEL-DUGAN, Cynthia; SHIPPS, Gerald, W., Jr.; MACCOSS, Malcolm
Patent: WO2011/46771 A1, 2011 ;
Location in patent: Page/Page column 139-140 ;
WO 2011/046771 A1
