1: p-methoxy-trans-cinnamylalcohol With [Rh(acac)2(CO)2]; C17H20NOP; toluene-4-sulfonic acid in benzene T=45°C; 0.166667 h; Inert atmosphere; 2: carbon monoxide With hydrogen in benzene T=45°C; P=2585.81 Torr; 16 h; 3: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol Pinnick oxidation; 6 h; Inert atmosphere; regioselective reaction;

toluene-4-sulfonic acid in toluene 0.333333 h; Heating;

1: 2-(4-methoxyphenyl)-acetic acid With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78 - 20°C; 1.08333 h; Inert atmosphere; 2: ethylene glycol cyclic sulfate in tetrahydrofuran; ethylene glycol dimethyl ether; hexane 16 h; Inert atmosphereReflux;

1: 4-methoxyphenyl triflate With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; anhydrous lithium acetate; palladium diacetate in tert-butyl methyl ether T=25°C; 0.166667 h; Inert atmosphereGlovebox; 2: γ-butyrolactone trimethylsilyl enol ether in tert-butyl methyl ether T=25°C; 2 h; Inert atmosphereGlovebox; enantioselective reaction;

1: 31 percent / LDA; BF3*Et2O / tetrahydrofuran / -78 - 10 °C 2: 100 percent / PTSA / toluene / 0.33 h / Heating View Scheme

1.1: n-hexyl lithium / tetrahydrofuran; hexane / -78 - 0 °C / Inert atmosphere 1.2: 0 - 30 °C / Inert atmosphere 2.1: hydrogenchloride; water / 1 h / 30 °C / pH 1 View Scheme