(R)-1-Boc-3-哌啶甲酸乙酯合成路线 （共 14 条）
反应条件
1: (R)-ethyl nipecotate (R,R)-hydrogen tartrate With hydrogenchloride T=60°C; Decomposition; 24 h; 2: di-tert-butyl dicarbonate With sodium hydroxide in tetrahydrofuran; water T=20°C; Acylation; pH=10; 12 h; Further stages.;
参考文献
Knapp; Zhao
Organic letters, 2000 , vol. 2, # 25 p. 4037 - 4040
反应条件
hydrogen; [Rh((S,S,R,R)-Tangphos)NBD][SbF6] in dichloromethane T=80°C; P=77572.2 Torr; 72 h;
参考文献
European Journal of Organic Chemistry, , # 19 p. 4343 - 4347
反应条件
anhydrous sodium hydrogen carbonate; sodium monohydrogen sulfate in tetrahydrofuran; n-heptane; ethyl acetate
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3235 - 3238
反应条件
1.1: 90 percent / H2 / 5 percent Pd-C / aq. ethanol / 36 h / 20 °C / 5171.48 Torr 2.1: BuLi / hexane / -78 °C 2.2: hexane 3.1: H2 / [Rh((S,S,R,R)-Tangphos)NBD][SbF6] / CH2Cl2 / 72 h / 80 °C / 77572.2 Torr View Scheme
参考文献
European Journal of Organic Chemistry, , # 19 p. 4343 - 4347
反应条件
1.1: BuLi / hexane / -78 °C 1.2: hexane 2.1: H2 / [Rh((S,S,R,R)-Tangphos)NBD][SbF6] / CH2Cl2 / 72 h / 80 °C / 77572.2 Torr View Scheme
参考文献
European Journal of Organic Chemistry, , # 19 p. 4343 - 4347
反应条件
diisobutylaluminium hydride in diethyl ether; water; toluene
参考文献
Novo Nordisk A/S
Patent: US6919315 B1, 2005 ;
反应条件
diisobutylaluminium hydride in diethyl ether; toluene T=-78°C; 2.5 h;
参考文献
Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 6 p. 487 - 501
反应条件
diisobutylaluminium hydride in diethyl ether; water; toluene
参考文献
Novo Nordisk A/S
Patent: US6919315 B1, 2005 ;
反应条件
1: DIBAL / toluene; diethyl ether / 2.5 h / -78 °C 2: 866 mg / NaB(OAc)3H; AcOH; molecular sieves / CH2Cl2; ethanol / 16 h / 20 °C View Scheme
参考文献
Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 6 p. 487 - 501
