(R)-1-BOC-3-哌啶甲醛合成路线 （共 7 条）
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 0.5 h; 2: With triethylamine in dichloromethane T=-78 - 20°C; 0.5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/118531 A1, 2005 ;
Location in patent: Page/Page column 74 ;
WO 2005/118531 A1
反应条件
diisobutylaluminium hydride in dichloromethane; cyclohexane T=-70 - 0°C; 0.666667 h;
参考文献
PanThera Biopharma, LLC
Patent: US2010/286125 A1, 2010 ;
Location in patent: Page/Page column 30 ;
反应条件
diisobutylaluminium hydride in diethyl ether; water; toluene
参考文献
Novo Nordisk A/S
Patent: US6919315 B1, 2005 ;
反应条件
diisobutylaluminium hydride in diethyl ether; toluene T=-78°C; 2.5 h;
参考文献
Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 6 p. 487 - 501
反应条件
1: 4.13 g / aq. NaOH / tetrahydrofuran / 16 h / 20 °C 2: DIBAL / toluene; diethyl ether / 2.5 h / -78 °C View Scheme
参考文献
Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 6 p. 487 - 501
反应条件
ammonium hydroxide; sodium hydroxide; sodium tris(acetoxy)borohydride; acetic acid; dimethyl amine in methanol; ethanol; dichloromethane; tert-butyl methyl ether
参考文献
Novo Nordisk A/S
Patent: US6919315 B1, 2005 ;
反应条件
molecular sieve; sodium tris(acetoxy)borohydride; acetic acid in ethanol; dichloromethane T=20°C; 16 h;
参考文献
Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 6 p. 487 - 501
