2-氨基-4-(3-甲氧基苯基)-1H-吡咯-3-甲腈合成路线 （共 5 条）
反应条件
sodium ethanolate in ethanol T=55°C;
参考文献
Novartis AG
Patent: US6051577 A1, 2000 ;
US 6051577 A
反应条件
1: NaN3; CH3N[(CH2)7CH3]3Cl / toluene / 55 °C 2: H2; HCl / Pt/C / methanol 3: Et3N / tetrahydrofuran / 20 °C 4: NaOEt / ethanol / 55 °C View Scheme
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
反应条件
1: H2; HCl / Pt/C / methanol 2: Et3N / tetrahydrofuran / 20 °C 3: NaOEt / ethanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 6 p. 849 - 852
反应条件
1: Et3N / tetrahydrofuran / 20 °C 2: NaOEt / ethanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 6 p. 849 - 852
反应条件
1: T=80°C; 2: With ammonia in methanol T=20°C;
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
