1-甲基-1H-咪唑-4,5-二甲腈合成路线 （共 18 条）
反应条件
1: 75 percent / sodium hydroxide / Heating 2: acetic anhydride / 95 - 100 °C View Scheme
参考文献
O'Connell, John F.; Parquette, Jonathan; Yelle, William E.; Wang, Wilhelm; Rapoport, Henry
Synthesis, 1988 , # 10 p. 767 - 771
反应条件
1: 75 percent / sodium hydroxide / Heating 2: acetic anhydride / 95 - 100 °C View Scheme
参考文献
O'Connell, John F.; Parquette, Jonathan; Yelle, William E.; Wang, Wilhelm; Rapoport, Henry
Synthesis, 1988 , # 10 p. 767 - 771
反应条件
1: 81 percent / aq. NaOH / 2 h / Heating 2: 95 percent / Ac2O / 4 h / 100 °C 3: 64 percent / SOCl2 / 24 h / Heating 4: 83 percent / NBS / AIBN / CCl4 / 50 h / 60 °C View Scheme
参考文献
O'Connell, John F.; Parquette, Jonathan; Yelle, William E.; Wang, Wilhelm; Rapoport, Henry
Synthesis, 1988 , # 10 p. 767 - 771
反应条件
potassium hydroxide 9 h; Heating;
参考文献
Bierer, Donald E.; O'Connell, John F.; Parquette, Jon R.; Thompson, Charles M.; Rapoport, Henry
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1390 - 1405
反应条件
1.1: 75 percent / sodium hydroxide / Heating 2.1: acetic anhydride / 95 - 100 °C 2.2: 60 percent / thionyl chloride / Heating View Scheme
参考文献
O'Connell, John F.; Parquette, Jonathan; Yelle, William E.; Wang, Wilhelm; Rapoport, Henry
Synthesis, 1988 , # 10 p. 767 - 771
反应条件
1.1: 75 percent / sodium hydroxide / Heating 2.1: acetic anhydride / 95 - 100 °C 2.2: thionyl chloride / Heating View Scheme
参考文献
O'Connell, John F.; Parquette, Jonathan; Yelle, William E.; Wang, Wilhelm; Rapoport, Henry
Synthesis, 1988 , # 10 p. 767 - 771
反应条件
1: 81 percent / aq. NaOH / 2 h / Heating 2: 95 percent / Ac2O / 4 h / 100 °C 3: 64 percent / SOCl2 / 24 h / Heating 4: 81 percent / NBA, CBrCl3 / AIBN / CCl4 / 60 h / 50 °C View Scheme
参考文献
O'Connell, John F.; Parquette, Jonathan; Yelle, William E.; Wang, Wilhelm; Rapoport, Henry
Synthesis, 1988 , # 10 p. 767 - 771
反应条件
1: 56 percent / (i-Bu)2AlH / toluene / 4 h / Ambient temperature
2: 31 percent / NaOMe / methanol / 0.17 h / 0 °C
View Scheme
参考文献
El Borai, M.; Hassenein, M.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 5 p. 853 - 856
