8-噁-2-氮杂螺[4.5]-3-癸酮合成路线 (共 2 条)
反应条件
ammonia; hydrogen; Ra-Ni in ethanol T=30°C; P=2378.88 Torr; 24 h;
参考文献
Bryans, Justin S.; Davies, Natasha; Gee, Nicolas S.; Dissanayake, Visaka U. K.; Ratcliffe, Giles S.; Horwell, David C.; Kneen, Clare O.; Morrell, Andrew I.; Oles, Ryszard J.; O'Toole, John C.; Perkins, Gemma M.; Singh, Lakhbir; Suman-Chauhan, Nirmala; O'Neill, Jacqueline A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1838 - 1845
反应条件
hydrogenchloride 1.) RT, 24 h, 2.) RT, 20 h; Multistep reaction;
参考文献
Bryans, Justin S.; Davies, Natasha; Gee, Nicolas S.; Dissanayake, Visaka U. K.; Ratcliffe, Giles S.; Horwell, David C.; Kneen, Clare O.; Morrell, Andrew I.; Oles, Ryszard J.; O'Toole, John C.; Perkins, Gemma M.; Singh, Lakhbir; Suman-Chauhan, Nirmala; O'Neill, Jacqueline A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1838 - 1845