trifluoroacetic acid T=4°C; 24 h;

1: 78 percent / potassium tert-butoxide / tetrahydrofuran; dimethylsulfoxide / 0.75 h / 23 °C 2: 77 percent / LiAlH4 / tetrahydrofuran / 3 h 3: 84 percent / pyridine / 4 °C 4: 77 percent / HgO, BF3*Et2O / 0.5 h 5: 94 percent / 0.2 M NaOMe / methanol / 16 h / 4 °C 6: 83 percent / 0.01 M trifluoroacetic acid / 24 h / 4 °C View Scheme

1: 84 percent / pyridine / 4 °C 2: 77 percent / HgO, BF3*Et2O / 0.5 h 3: 94 percent / 0.2 M NaOMe / methanol / 16 h / 4 °C 4: 83 percent / 0.01 M trifluoroacetic acid / 24 h / 4 °C View Scheme

1: 77 percent / LiAlH4 / tetrahydrofuran / 3 h 2: 84 percent / pyridine / 4 °C 3: 77 percent / HgO, BF3*Et2O / 0.5 h 4: 94 percent / 0.2 M NaOMe / methanol / 16 h / 4 °C 5: 83 percent / 0.01 M trifluoroacetic acid / 24 h / 4 °C View Scheme

1: 94 percent / 0.2 M NaOMe / methanol / 16 h / 4 °C 2: 83 percent / 0.01 M trifluoroacetic acid / 24 h / 4 °C View Scheme

暂无反应条件数据

1: hydrogen chloride 2: zinc chloride 3: pyridine 4: platinum; aqueous methanol / Hydrogenation 5: aqueous sulfuric acid View Scheme