吡啶-2-YL二苯基甲醇合成路线 （共 20 条）
反应条件
phosphorus; iodine; acetic acid
参考文献
Otto et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 446,450
反应条件
tert.-butyl lithium in tetrahydrofuran; pentane
T=-78 - 20°C; 6 h; diastereoselective reaction;
参考文献
Goto, Sachio; Velder, Janna; El Sheikh, Sherif; Sakamoto, Yuki; Mitani, Masatoshi; Elmas, Said; Adler, Andreas; Becker, Anne; Neudoerfl, Joerg-Martin; Lex, Johann; Schmalz, Hans-Guenther
Synlett, 2008 , # 9 p. 1361 - 1365
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran
T=-70°C; 2.33333 h;
2: benzophenone in tetrahydrofuran
T=-70 - 20°C; 5.5 h;
参考文献
MEDIVIR AB
Patent: WO2005/65689 A1, 2005 ;
Location in patent: Page/Page column 48-49 ;
反应条件
1: alpha-chloropyridine With magnesium in tetrahydrofuran
T=0°C; 0.0833333 h;
2: benzophenone in tetrahydrofuran
T=25°C; Grignard reaction; 1 h; Further stages.;
参考文献
Sugimoto, Osamu; Yamada, Shigeru; Tanji, Ken-Ichi
Journal of Organic Chemistry, 2003 , vol. 68, # 5 p. 2054 - 2057
反应条件
magnesium in tetrahydrofuran
T=20°C; Barbier reaction; 0.5 h;
参考文献
Sugimoto, Osamu; Yamada, Shigeru; Tanji, Ken-Ichi
Journal of Organic Chemistry, 2003 , vol. 68, # 5 p. 2054 - 2057
反应条件
pyridinium trifluoroacetate in ethanol
24 h; Heating;
参考文献
Effenberger, Franz; Koenig, Joachim
Tetrahedron, 1988 , vol. 44, # 11 p. 3281 - 3288
反应条件
sodium in xylene
3 h; Heating;
参考文献
Goe, Gerald L.; Hillstrom, Gregory F.; Murugan, Ramiah; Scriven, Eric F. V.; Sherman, Angela R.
Heterocycles, 1994 , vol. 37, # 3 p. 1489 - 1494
参考文献
Ashworth et al.
Journal of the Chemical Society, 1939 , p. 809,811
反应条件
2-pyridine carbonitrile; hydrogenchloride in water; isopropyl alcohol
17 h; Irradiation;
参考文献
Caronna, Tullio; Morrocchi, Sergio; Vittimberga, Bruno M.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 399 - 400
参考文献
Witkop; Patrick
Journal of the American Chemical Society, 1951 , vol. 73, p. 2188,2190
Full Text Show Details
Kasuya
Yakugaku Zasshi, 1958 , vol. 78, p. 509
Chem.Abstr., 1958 , p. 17196
